I have been on Lyrica [and then the generic form, which is Pregabalin] for about 15 years since it first came out, and was prescribed for Fibromyalgia, Fibro is body wide nerve pain, among many other syndromes that accompany fibro. I have been on various medication for it for 24 years. It is still a misunderstood disease. In response to this original question, which is about Lyrica, it helps very much for all of my pain. Pain never goes away but Lyrica makes it more bearable. I have learned over these 24 years that I must be responsible for learning about how my brain expresses pain. What helps many of us is Deep breathing, which calms the mind, low impact [light] exercise, progressive muscle relaxation, massage therapy, and more. Much of these things can be learned on Youtube!! I learned about true deep breathing by the video Dr Chris Dula Relax, on Youtube. It is life altering. Lyrica caused about 10 pounds of weight gain, but absolutely NOT 100 pounds. This is because it changes something about when we feel sated after eating. I would have ended my life years ago without Lyrica. A person has to work with the doctor until YOU reach the dose that helps YOUR pain. Every single person responds differently.