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@kujhawk1978

So in part, the answer may lie in other clinical data...

You've given the biopsy piece, other clinical data which may be useful for members of this forum, you and your medical team:

Co-morbidities..even without treatment, it could be 8-10 years before serious problems with your PCa present themselves, will you be here?
PSA results - useful for calculating PSA doubling time and velocity
Imaging - Either the tried, not necessarily true, but what some insurance companies require - MRI and CT or one of the recent ones, a PSMA PET.

You say so many side effects, no matter what treatment you decide on, there will be side effects. In part, the experience of your team, whether radiation or surgery, play a role. When I had surgery in 2014, no incontinence, it was nerve sparing, regained erectile function in roughly 12 months. I have three different radiation treatments (see my clinical history, attached), SRT to the prostate bed, WPLN and SBRT. Zero side effects. Being a member of my medical team is a privilege, not a right, you need to know your stuff - "As a member of my medical team, you should have a thorough knowledge of my cancer and of the latest developments in research, and be ready to formulate a plan of attack."

As others have said, with surgery, side effects are generally immediate and gradually get better though many on this and other forums express great dissatisfaction with ED results. Radiation to the prostate and prostate bad can "fry" the nerves and you wind up with ED, just as with surgery.

You say you just want to "get rid of the cancer..," MSCKCC has nomograms for calculating the risk of recurrence after surgery, mine was 30%, you guessed it, winner, winner...Here's the link - https://www.mskcc.org/nomograms/prostate

I would begin with reviewing the NCCN Guidelines for patients - https://www.nccn.org/guidelines/category_1, that would be my starting point for discussion with my medical team. The NCCN also offers free resources for patients, called the NCCN Guidelines for Patients, which provide expert information about cancer treatment options. These resources are presented in plain language with visuals, charts, and definitions to help people with cancer and their caregivers discuss treatment options with their clinicians.

There are other resources, Prostate Cancer Foundation has a patient guide - https://www.pcf.org/guide/

I would start learning and use the terminology, when you say "hormone doctor..." that leaves us pondering who you are getting advice from. Generally the prostate cancer team is multi-disciplinary, urologist, often the surgeon, the radiation oncologist and a medical oncologist., add a cardiologist, dietitian,...Any of these three can prescribe hormone treatment, this last go round my radiation oncologist prescribed my Orgovyx.

There is "good" news...you have lots of choices. That is also not so "good" news as it may make decision making "difficult." Examples include doublet or triplet therapy - https://dailynews.ascopubs.org/do/would-you-use-doublet-therapy-and-not-triplet-therapy-patient-newly-diagnosed-mhspc. Why combination therapy - "Why combination therapy - heterogeneity and evolvability, via genetic or nongenetic mechanisms, are two of the greatest obstacles to the successful treatment of cancers..."

Here's one of my rules which has served me well these 10+ years after my urologist said "Kevin, that's a pretty aggressive cancer..." when reviewing my biopsy results:

"Walk in the door ready to start the conversation at a different level. I don’t have to spend time talking about the basics, things like Gleason grade and clinical stage and what they mean. I already know. I can have an intelligent discussion about the merits of a particularly treatment for my cancer, my likelihood of being cured, and risk of side effects."

Members of this forum can provide their thoughts based on their experience, but your cancer is not ours. My advice - Consider the age of any treatment statistics you find. New advances quickly make them obsolete. Be careful about applying statistics to your own situation. You are an individual, not a statistic.

Kevin

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Replies to "So in part, the answer may lie in other clinical data... You've given the biopsy piece,..."

Excellent post.