My doctor doesn't use bone markers at all. He says an entire conference could be focused on this issue. He says that they don't tell the whole story about what is going on in bones. I do know that kidney issues can affect CTX, along with food and time of day.

I went to another doctor who does do bone markers, as a second opinion, as well as Keith McCormick, but so far my bone marker testing has not been particularly helpful and the results don't seem to match expectations, probably because they were not done at the proper times, but who knows. I am not really worrying about bone markers being done at this point, but hope they help others guide treatment.