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Tracking Results with Evenity

Osteoporosis & Bone Health | Last Active: Jun 28 9:57am | Replies (7)

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@mayblin

Here you go, then download the pdf from there:
https://scholar.google.com/scholar_lookup?&title=Romosozumab%20%28sclerostin%20monoclonal%20antibody%29%20versus%20teriparatide%20in%20postmenopausal%20women%20with%20osteoporosis%20transitioning%20from%20oral%20bisphosphonate%20therapy%3A%20a%20randomised%2C%20open-label%2C%20phase%203%20trial&journal=Lancet&doi=10.1016%2FS0140-6736%2817%2931613-6&volume=390&pages=1585-1594&publication_year=2017&author=Langdahl%2CBL&author=Libanati%2CC&author=Crittenden%2CDB&author=Bolognese%2CMA&author=Brown%2CJP&author=Daizadeh%2CNS&author=Dokoupilova%2CE&author=Engelke%2CK&author=Finkelstein%2CJS&author=Genant%2CHK&author=Goemaere%2CS&author=Hyldstrup%2CL&author=Jodar-Gimeno%2CE&author=Keaveny%2CTM&author=Kendler%2CD&author=Lakatos%2CP&author=Maddox%2CJ&author=Malouf%2CJ&author=Massari%2CFE&author=Molina%2CJF&author=Ulla%2CMR&author=Grauer%2CA
Ideally, for a treatment naive patient to start an anabolic, it's best to get a baseline of both p1np and ctx then monitor their changes periodically after the start of treatment. The dynamic changes between the two will indicate anabolic effects (or not). In this particular alendronate to evenity sequencing, the ctx is suppressed to start with and remained almost flatlined during therapy, it will be more important to monitor p1np, especially during the initial phase of evenity, i.e., at 2weeks or 1 month. I think waiting till 2-3mo into the start of evenity to test bone markers will be too late, this is evident as shown in fig5. Getting both bone markers tested wont hurt, might be better, but p1np for sure for this sequencing. It is intersting to note that this trial compared evenity vs forteo following fosamax. The forteo arm showed a much attenuated effect when compared to evenity. Since treatment length being 1 year, we don't know if 2 year treatment of forteo would have a different outcome.

Definitely ask your doc to order bone markers, this will allow the lab to bill insurance, whereas you'd pay out of pocket if you were to order the lab online on your own.

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Replies to "Here you go, then download the pdf from there: https://scholar.google.com/scholar_lookup?&title=Romosozumab%20%28sclerostin%20monoclonal%20antibody%29%20versus%20teriparatide%20in%20postmenopausal%20women%20with%20osteoporosis%20transitioning%20from%20oral%20bisphosphonate%20therapy%3A%20a%20randomised%2C%20open-label%2C%20phase%203%20trial&journal=Lancet&doi=10.1016%2FS0140-6736%2817%2931613-6&volume=390&pages=1585-1594&publication_year=2017&author=Langdahl%2CBL&author=Libanati%2CC&author=Crittenden%2CDB&author=Bolognese%2CMA&author=Brown%2CJP&author=Daizadeh%2CNS&author=Dokoupilova%2CE&author=Engelke%2CK&author=Finkelstein%2CJS&author=Genant%2CHK&author=Goemaere%2CS&author=Hyldstrup%2CL&author=Jodar-Gimeno%2CE&author=Keaveny%2CTM&author=Kendler%2CD&author=Lakatos%2CP&author=Maddox%2CJ&author=Malouf%2CJ&author=Massari%2CFE&author=Molina%2CJF&author=Ulla%2CMR&author=Grauer%2CA Ideally, for a treatment naive patient..."

Thanks so much, @mayblin I've downloaded it and will read it. Don't know if my insurance will cover the BTMs but worth a try.