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Has anyone with UC stopped responding to Entyvio?

Digestive Health | Last Active: Jul 7 12:41pm | Replies (60)

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@dmw653

I am in the same boat you are. Entyvio stopped working and now my doctor wants to start me on Stelara. I see this post is fairly old. How did you do?

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Replies to "I am in the same boat you are. Entyvio stopped working and now my doctor wants..."

Sadly, the Stelara did not work. Had the loading dose (IV) and then the first subQ shot and ended up hospitalized the next day. Back on high doses of prednisone (IV and oral) and then started Remicade. The standard Remicade dose (5mg/kg) worked initially during the loading dose period and then not so much. GI doc did battle with my insurance company to get authorization for a higher dose (10 mg/kg) every 4 weeks. I was so malnourished at that point in time, I was under 100 pounds and the clinical recommendation was 110 pounds. GI doc is tenacious and finally got approval (2 weeks before I was supposed to have scheduled proctocolectomy). The higher dose worked!! I was able to cancel the surgery and have been in remission for 2.5 years! I am still getting the Remicade infusions (the higher dose) but every 6 weeks now. GI doc does therapeutic drug monitoring to check inflammation levels, trough levels and antibody titers to make sure Remicade is still working and that I have not developed antibodies. That’s what happened with the Entyvio. So I am happy to report that the Remicade continues to keep me in remission. I also follow a whole food, plant based diet, which seems to help me. I have been maintaining my weight (110 pounds) and feel good for the most part… I am cautiously optimistic that this will continue. If not, there have been several newer drugs approved over the past few years, so if it gets bad again, there is some hope… I wish you the very best and I hope I have answered your question.