After much trial and error (mostly error), I take 1000 mg (1 gram) Tylenol an hour or so before I go to bed which (usually between 11 and 12. I take 50 mg Tramadol about 1/2 hour before bed. That combo usually lasts 2 to 2 1/2 hours before pain returns. and I awaken. I am usually up for abut I hour during which I repeat the Tylenol-Tramadol combo. Often, I find that I might have to take 500 mg Tylenol a couple of hours later. Thus, in general, I get about 4 to 5 hours sleep although broken up. Again, I repeat, I DO NOT take any homeopathic meds, nor do I use any devices sold by the ESO people. ESO means Electronic Shake Oil). Also please be careful to not overtake the Tramadol and Tylenol. Best of Luck.