@gently the surprise was that me P1NP was low. My CTX was too. But at that point I had excellent gains. I was told by two doctors and McCormick that the effect had waned as it usually does at some point. I stayed on Tymlos another 6 months to complete the 2 years and was told I was probably safe to do that, but I also wanted to really explore the next steps, which ended up being Evenity before Reclast. My P1NP was low with Evenity too. Timing of testing has never been ideal for me. My doctor doesn't do bone marker testing so I have to arrange myself.
ps I thought it was pretty well-known that these drugs peter out over a year or year and a half...the question now, as you well know, is if and when we can again get a boost from them, especially after bisphosphonates short term