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Orgovyx and Diltiazem: Should I be concerned about drug interactions?

Prostate Cancer | Last Active: Jul 10 4:52pm | Replies (7)
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@northoftheborder

I was taking Diltiazem as a second hypertension drug (not for afib), but stopped it when I had to begin ADT and ARSI.

The list of potential interactions for our prostate-cancer medications is huge, so this is a hard situation to avoid. I am still on some other meds that can potentially have serious interactions with Orgovyx and Apalutamide, but so far everything's been fine (after a few weeks of close monitoring).

It's a tough decision, and I wish you well.

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Replies to "I was taking Diltiazem as a second hypertension drug (not for afib), but stopped it when..."
ggimlick | @ggimlick | Jun 25 5:58pm

Thanks for you info. The cardiologist has signed off on concurrent use and will do an EKG after one week. I start Orogvyx tomorrow. Diltiazem is considered a moderate or weak P-gp inhibitor depending on the source so they feel it’s a safe bet, but will monitor for side effects. Strong inhibitors can increase the levels of Orgovyx by 6 times.

I guess we'll "fly it and watch it" as they told us in Army aviation.

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