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Signatera testing: Has anyone had this done?

Pancreatic Cancer | Last Active: Jul 4 9:00am | Replies (33)

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@mse

I had a colon cancer mass that was completely blocking my colon, surgically removed in January 2024 -- stage IIA, clear margins, 40 lymph nodes removed, all of which tested negative. I've had no history of any cancer prior to that time. Based in part on my first Signatera evaluation, which came back 0.0, I did not receive chemo or radiation. Reversal surgery for my ostomy bag was done in May, 2024. CT scans done in March, 2024 showed no lesions in any organ in my abdomen. My second Signatera test just came back negative -- 0.0 -- yesterday, June 24, 2024. These test results coincided with my CT scan also done last week, which showed four cancerous tumors in my liver which had not been there in the March CT scan. My oncologist has ordered a biopsy this week. He was rather stunned that this had occurred ... needless to say, so am I.

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Replies to "I had a colon cancer mass that was completely blocking my colon, surgically removed in January..."

When I was offered Signatera testing I was told from the beginning that a negative result is not definitive-a positive result is.
My oncologist does tumor marker CA19-9 every two weeks. I understand it is less expensive than Signatera. In my case, the TM tracks the disease quite well. If TM is in normal state, that is when I “backfill” with Signatera. Either way, hopefully you will have a PET soon to confirm the liver activity. If the tumors are close together, ask about Y-90 procedure post chemo

@mse, you may wish to follow the Colorectal Cancer Support Group here: https://connect.mayoclinic.org/group/colorectal-cancer/

What did you learn from the biopsy? How are you doing?