Pearlmarie here. I have severe OA and chronic pain since 1995. I have had 2 TKR, and a plate and pin in my ankle due to a serious break. I also have degenerative disc disease. Over the years my pain has become more severe which affects my activity level. The docs here in MA will not prescribe pain meds of any kind. They expect tylenol will do the job. Sorry, but that doesn't work for severe pain. I just want some relief so I can at least walk with some degree of comfort.