I think and particularly my case the sooner you can get off prednisone the easier it will be. If you have been on for years it gets really difficult to taper off. As soon as you reach the cortisol wall it can easily restart the PMR. When I tapered my research into this drug was when I reached the taper wall and could barely get out of bed I then bumped it back up for a couple of days. My taper wall was 5 mg. So i went back to 10mg for a couple days then dropped to 5. It seemed if i went back to 5mg the pain stayed with me. I needed to go up higher. If your pituitary is trying to restart and your PMR markers are good you should be able to go back and forth in just a few days. The longer you stay at say the 10mg the harder to move back down. By bumping it , I mean just keep trying to push up against that taper wall. Go in smaller increments but whatever your wall is just keep pushing(bumping) it to the pain level. There will be some pain. In about 6 weeks I was able to go from the 5mg to off. This worked for me.