I too am super sensitive. I had the worst experience of my life for 2 days (I won't lie!). THEN I was told that that is GOOD and it will only happen that first time! It meant that the medication targeted needed areas and stimulated my own system to jump-start the bone-building! I was told next time to take tylenol beforehand. Get pain meds onboard beforehand. This is familar too me from a previous experience. My body ramps up to attack the problem induced by the medications. I am having a parallel experience with the Tymlos now. I am at the full dose of Tymlos but it might be too much for me. I am trying to explore a reduction but my doctors/nurses don't have any experience with my inquiries about medication reduction. The pharmaceutical companies do however - you can call them to find out more and you can ask your doctors to find out more. Being hypersensitive I always need to take less of stuff. But honestly have found the knowledge base at my doctors inadequate. So I'm just hanging in there and pushing them to get more info for now. Good luck.