After about 3 years of normal tests then my tests started having higher numbers. That’s went on for 3 years and many many CT scans etc. during that time I was diagnosed with RA. Finally my RA meds helped and now my CA 27 tests have been in the normal range except one time during an RA flare up. I do believe it is related. I had my lumpectomy 12 years ago. My doctor still does the CA 27 test and last one was 30.