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@patj605

Are MAOIs an option or have you already tried this class of ADs? They’re often turned to in cases of TRD. My success with them has been limited but hope springs eternal. I’m taking Marplan now after not getting any prolonged help from Nardil and Parnate. I had ECT years ago and I now regret it.

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Replies to "Are MAOIs an option or have you already tried this class of ADs? They’re often turned..."

All I can say as thank goodness SSRI’s came along. They have side effects but nothing like the previous generation of antidepressants.
Hopefully the next generation will be even more targeted to the areas of the brain that causes depression and anxiety. That appears to be the next hurdle and would eliminate so many side effects.
If anyone has found one without side effects let everyone know.
That will be the equivalent of restoring hair cells inside the ear for people like me with severe hearing loss. It is coming but not quickly enough.