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Hello, I joined today to get help in deciding what medication to begin

Osteoporosis & Bone Health | Last Active: Aug 11 10:11pm | Replies (70)
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@windyshores

@isabelle7 Evenity is a very different drug than Fosamax with a very different mechanism. It is a potent bone builder with anti-resorptive properties in the last month (and Fosamax is an anti-resorptive). Evenity works by inhibiting sclerostin. Fosamax "poisons" osteoclasts that carry out bone turnover.

I chose Tymlos because the dose was adjustable. Years before I had tried Forteo but could not tolerate it. Tymlos worked really well for me.

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isabelle7 | @isabelle7 | Jun 23 9:51am

@windyshores

Thanks for the info. I remember you saying one was good for adjusting the dose but couldn't remember which one. Thanks for clarifying. It's great that there's an alternative to the Forteo if for some reason it doesn't work for someone. So good to know.

Have you taken Evenity? I'm still a little confused as to when a person would take which drug.

My takeaway is that for my husband's condition (steroid-induced osteoporosis with a -3.4 lumber spine t-score) it would be best to start with Forteo for about two years. Then go on either Fosamax or Reclast. Where I'm confused is - when does Evennity come into the picture? Would it be in addition to say Forteo and Reclast or would it be instead of one of those, and at which time?

I'm sorry for all the questions. Treating osteoporosis is quite confusing and complex especially when doctors don't seem to either know or bother to tell us what's best. They were just going to start him on Fosamax without using something like Forteo or Tymlos. He started on 30 mg prednisone in 5/2023 for PMR, tapered to 12.5 by 2/2024, developed GCA, at 80 mg for a month (with three 1200 mg infusions of prednisilone) in 2/2024 and has tapered to 20 mg using Actemra weekly injections.

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