Cymbalta did help my pain and overall that was great...but it did make me feel weird. Can't really describe it. However I have issues with constipation and after 5 days of having no bowel movement I stopped it (took a Dulcolax with my daily stool softener and 'amatiza). I went 9 days after my TKR and was backed up to my distal colon so this was not an option for me. I only took 20mg then tried 10mg. Still a no go. I do take 900mg Gabapentin at bedtime and that is well tolerated. I have to be careful with any Nsaids as well and Cox 2 inhibitors which I don't really take. Best of luck. It's hard when the options are so limited.