Hello @cindymattern, I combined your new discussion with your first discussion on your piriformis muscle issues and your cortisone shot.

I updated the title a bit to help other members join your discussion, "Post-TKR Piriformis Syndrome - Cortisone Shot?" - https://connect.mayoclinic.org/discussion/piriformis-syndrome-1.

I have many lower joint issues as well (fused ankle, end-stage arthritis in other ankle and a total knee replacement that is 18 years old in my right knee). I know that when one area of my lower body is hurting that I subconsciously compensate and by doing so I disturb other joints or muscles. For me, this causes a "jumping around" of my pain points. They seem to go from one area to the next and so on.

How is your mobility during the day now that you are 4 days removed from your cortisone shot? Are you able to move more during the day and is your pain maybe "catching up" to you at night? I notice my pain and swelling most when I finally settle in for the evening and the day catches up to me.