All of my "aging" problems occured after stopping HRT. I did Bio-Identical HRT for 8 or 10 years. I did it topically (rubbing it into the skin.) It worked GREAT for me. For all the "girlie" problems - to maintain skin, muscles and bones. Hormones keep us youthful. However, I had to balance cancer risks with estrogen products so the bioidenticals were the answer - to be compounded in the proportions I needed. The first year was finding the right combo of estrogen, progesterone, and testosterone in the right amounts. I was very pleased. It was a bit of a struggle to get it all in place. But I used so little every day that it wasn't expensive (I had to pay out of pocket). Kept EVERYTHING in the right balance. I highly recommend it!