I took Fosamax just once. I have GERD and it went NUTS! I am normally able to control it with being a healthy weight, eating 4-5 small meals instead of just one, never eating after 6pm for a 10 pm bedtime, no alcohol, sleep my first several hours on my right side, with my bed tilted so my head is 10" above my feet. But the Fosamax created AGONY. It's the only OP drug I have tried.