Hi joann,

Thank you for sharing your story. The purpose of this thread is for those of us transitioning from Prolia to share our knowledge and experience to help each other make a successful transition

From material that I have read, once you have taken more than 4 Prolia shots, you usually need a more potent bisphosphonate to stave off the rebound effect. In your case, having been on Prolia for 4.5 years, Fosamax may not be potent enough and Reclast is usually precribed as the follow-on drug. Having said that, i don't think it necessarily means that Fosamax will definitely not be effective. I personally think (i.e. not supported by anything I have read) that it's possible that, for those with low baseline CTX, the rebound might be weaker and Fosamax may prove to be adequate. But it does mean that you need to very carefully and frequently monitor your CTX. From your previous post, I gather that you have never had any CTX done before and you do not have any baseline number. Nevertheless, i think it is still important to monitor your CTX and compare it with the relevant recommended range. A very high CTX number may give an early signal that Fosamax is not effective and that you need to consider Reclast instead

All the best and I hope you will keep us updated on your transitioning progress