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@lindabp

I have been on and off bupropion for years, was not able to take other antidepressants I tried (I’m now 80 so I’ve had depression most of my adult life). I’ve been on 300 mg for some time. Periodically I feel very agitated and still depressed- discussed changing w my provider but based on my history she thinks I should stay w this. I have found that different generics affect me greatly and have found a small private pharmacy that will continue to order the one generic that seems to work best. CVS/Walgreens etc only gets what the company orders in bulk. I hate this whole thing and sometimes think I might have been better off not to be on any but I think my system has adapted to needing it. Withdrawal is VERY scary and agitating for me even gradually. And I do think it affects my heart rate. Since I have AFib and other heart issues I worry it affects that. I do believe that Years on antidepressants affect your brain chemistry. I feel too old and have other health issues so I just bumble along. (Wow. That sure sounds like I’m depressed doesn’t it?). Very few practitioners in my area and mental health services almost a joke!

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Replies to "I have been on and off bupropion for years, was not able to take other antidepressants..."

Thank you for sharing your experience. You’re so right on many points. I to wonder if being on this long term is the best choice for me, and I only say that because I don’t have serious depression mine is in the form of having issues with food. I know that sounds ridiculous to most but I personally feel depression has many forms. Your experience on different generics is very interesting, I’ve never thought of that but it makes sense! I’ve considered a compound pharmacy to see if they have any ideas on lowering dose but adding something additional. Not sure it that’s a thing or not. Your post has me reflecting…greatly appreciate your input and honesty.

Having had a Lyme tick bite in NY in 1979 and went undiagnosed for 12 yrs, it was necessary to find an antidepressant that helped with the relentless symptoms that by the time I was diagnosed the bacteria had become a full fledge cornucopia of systemic pain and ongoing symptoms I was given trintellex and it was like magic. I went off it gradually as Lyme symptoms lessened with more abx and I thought I was out of the woods. Not so - then onto Wellbutrin genetic. Did absolutely nothing and I persisted for months. Why must we subject ourselves to less than effective meds when clearly they don’t have answers for the originating symptoms in my and perhaps your case? My daughter is a clear cut case of severe mental illness and she’s been given meds that have made her delirious. I don’t think we have a medical establishment that to this day will admit they are “handicapped”. We are pumped full of pills in an effort to quiet us down, hopefully resolve a host of problems yet we continue to suffer from either true clinical or even mood disorders such as mine which is an originating bacterial bite from a tick that still is not recognized by the medical Profession? We are severely under the ongoing presence of doctors who clearly do not know how to listen and prescribe.

Linda I believe the 300mg affected my heart rate as well and it was pretty scary, stayed up most of the night for a few nights to monitor it. I understand the bumbling along due to needing many other medications at my age but will get into my big girl pants and try and deal with this! Another scary reported side effect is hair loss, pure vanity but that I cannot afford. Thank you for your thoughts, I wish you well.