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DiscussionEvenity treatment and its effectiveness
Osteoporosis & Bone Health | Last Active: Sep 10 4:49pm | Replies (46)Comment receiving replies
Replies to "You said "sometimes a dr wold like to use bone markers to monitor preliminary response". I..."
ripley,
Neither my endocrinologist nor my rheumatologist ordered bone markers. I asked the rheumatologist to order them. He looked up the tests right in front of me and we discussed. He said, “Sure. No problem.” So, he did order them, I received results, no doc has called me to discuss. I also had a dexa a few weeks ago and no doc has called to discuss that.
Thursday, I am having a Reclast infusion in the rheumatologist’s office. While there, I plan to inquire and complain.
@ripley I think the statement made by the endo you saw recently was correct and incorrect at the same time. S/he is right since for the majority of people, CTX or P1NP will fall in the "normal" range with rare exceptions. However, if we look at the two bone markers in reference with each other, the picture could be totally different. For example, for two different persons having a same P1NP reading of 50, the person with a high CTX in 600s will be considered an abnormal high turnoverer resulting bone loss, when compared with the other person with a CTX in 300s. After many readings, I think for a treatment naive person, ideally it's best to have multiple baseline btms done in a span of 6-12 months. Then using the average of the readings as a true baseline to "smooth" out variability. If, the anuual dexa scan shows bone loss, then you'd know you are losing bone with this baseline of btms. It's evident that the variability exists among individuals especially with the interference of different medical conditions. This might be the root for the difficulties in interpreting btms. I'm anthusiastic in using btms as a tool and convinced my endo ordering them periodically. Unforturenately btms have not incorporated in original accessement nor in treatment monitoring as a routine, although they were actively used in many clinical trials.
This is a Mayo Clinic article about Bone Turnover Markers
"Beyond bone density: Checking the health of your bones"
By Krupa B. Doshi, M.D. (Endocrinologist)
https://mcpress.mayoclinic.org/living-well/beyond-bone-density-checking-the-health-of-your-bones/
That’s not true that your markets would be normal .