I too feel very isolated as a sufferer of LC. I do not have a significant other and feel my siblings and adult children have zero understanding of how crippling this year. I am blessed to have a job that I can do remotely and allows me to continue to support myself financially and provides decent medical insurance. At times my brain function is not decreased and accomplishing my work is challenging. I try to keep my spirits up by focusing on what I do have. That too is difficult. And when I’m suffering from a bout of PEM, it’s easy to think of my life as one not worth living. I’m not saying I’m going to commit or try or even consider suicide. I’m saying thoughts and feelings about how miserable life is can spiral into not just feeling physically ill but also sap the willpower to keep trying to heal.