Hi. So sorry to hear of your struggles and I can relate to almost everything. I have been on all of the medications you had mentioned and then some. I was on Xolair for 15 years before it stopped working - and that was the beginning of biologics. I was on Tespire - and had gotten worse from it, but Dupixent has been better for me. Recently, was in hospital - 240mg of Steroids IV for 10 days - which was awful and finally tapered down to a "normal" level - but still on them and don't know if I will get off. Please see a cardiologist - as from all the steroids, you may have some cardiac issues which are now interfering with your recovery. I was also considered a "mystery" as to why my asthma has gotten much worse in the past 2 years +, being an asthmatic since I was a child. Also - Brovana (Arformoterol) - a 12 h - twice a day nebulizer has been helpful (this is long acting Albuterol), along with Budesonide nebulizer every 12 hours, have been helpful, along with daily medications. An old time medication - Theophylline is still around and can be helpful as well. Good luck and hope to hear that you are improving.