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Have been taking hydroxychloroquine for 18 years and I have never had any negative effects from this drug. I was also on methotrexate for five years but it was stopped because I simply didn’t need it any longer. I did have an episode of Polymalagia Rheumatica last year which was the most painful condition I ever had, and it sounds as though you are struggling with it too. Prednisone helped tremendously, but tapered off after six months. I am now suffering with terrible spine issues, and I’m not sure if PMR did its damage or not. Seeing a new neurosurgeon next week.