I looked it up, and I found a summary of vitamin B6 toxicity that said toxicity usually occurs with 1000 mg or more, but there are case reports of people who’ve experienced B6-related neuropathy when taking less than 500 mg per day for months.

“ Paradoxically the most common symptoms associated with vitamin B6 toxicity are similar to those with vitamin B6 deficiency. A patient will experience peripheral sensory neuropathy. Most commonly, this causes numbness in a stocking-glove distribution over the extremities. In addition to peripheral neuropathy, patients can experience ataxia and disequilibrium as well.”

For comparison’s sake, the recommended daily value is only around 1-2 mg per day, and a 100 mg supplement is “considered safe,” while up to 200 mg is “possibly considered safe.”

The Liquid IV I was taking 1-2x per day had 1.2 mg of B6.

I guess it depends on how your body responds to it? We found out it was a problem after I had labs checked for fatigue and neuropathy, so my B levels were checked. I don’t remember what the number was, but it was more than 200% of the upper limit. I still have neuropathy, but it was exacerbating it.