@susanfalcon good question and one that needs to be asked of our doctors! I have been told I might need 3 years of Reclast and then a drug holiday. DEXA and maybe bone marker monitoring will determine this.

Others have discussed reusing Forteo or Tymlos, which has also been mentioned by my doctor since Forteo can be taken more than two years. And Evenity has been discussed as potentially being given in short bursts between other drugs, since its anabolic action is a few months.

More research is needed, in a hurry. In the meantime I think the answer is, "it depents." Clealy no drug holidays with Prolia but with bisphosphonates, very possible even probable since they hang around n the body for a longer time. Reclast may even stick around for 10 years!