I've not met someone who started on methotrexate instead of prednisone, although it makes sense. Let us know how it's going.

I have an inflammatory arthritis, but I know others who have been on methotrexate and while prednisone definitely has its down sides, methotrexate did not sound like a picnic either. Even my dad's rheumatologist said: "Well we could use it to help you taper off prednisone, but that will present a whole host of other problems..." We stuck with the prednisone.

If you have problems, you could talk to your rheumatologist to consider a shorter course of prednisone to try to quash the worse of the inflammation and then go to methotrexate or one of the new biologics if your insurance will approve it to help you taper more quickly. It's possible it may not spike your blood sugar so severely. It didn't for my dad.