Hi , I’ve not taken Hydroxychloroquine to come off methotrexate. I was given it for my fibromyalgia. Unfortunately I developed a rash on my neck and face and was I couldn’t take it. I took methotrexate for my PsA . I had no adverse symptoms noticed until I had sepsis and it was discovered I had liver disease. They attribute this to years of anti inflammatory medications for autoimmune diseases, my autoimmune diseases themselves, and the methotrexate use. Can never take it again or any kind of anti inflammatory medication, Tylenol etc…