Hi marye2, My husband has had horrible 24/7 headache pain (which the Mayo Clinic diagnosed as New Daily Persistent Headache) for 20 years. NOTHING has relieved the pain. I finally ordered some CBD oil last week from a company recommended by a co-worker of mine. My husband started trying it two days ago and, of course, hasn't felt any relief yet. We are telling ourselves that it might take a few weeks before he notices any relief, so I was glad to read your comment that it took you about two weeks to see the effects. He started taking .5 MG first and may ramp up as needed. You mentioned that 5 mg is where to start. That seems like a lot to start. Did you mean .5 mg by chance? Thanks in advance for your assistance.