@debbie1956 that is a very insightful comment. The reality is that Evenity is so new that studies are still going on. I have read there is a study with a bunch of combinations (I won't remember them all): 6 months Evenity and 18 months Reclast, or 12 months Evenity and 12 months Reclast for instance. In that study the point is, can Reclast be substituted for the antiresorptive part of Evenity?

My doctor said they actually don't know everything about how Evenity works. It is actually not a strong anti-resorptive but is very potent because of its inhibition of sclerostin. We need more research and it will take time!

I don't like to say too much about my side effects because most people do so well with so few side effects on Evenity. I have lupus and neuropathy and some other things and have a history of weird sensations. Evenity gave me burning, tingling sensations that were beyond what I could tolerate and I tolerate a lot for my bones! A few others have had this but it is very rare. It is listed in side effects on the Evenity site as "tingling" and I have seen "paresthesias" listed as well.

Evenity "turbocharges" bone density/growth (I read that term!). I had some concerns about the function of sclerostin throughout the body but Evenity was only two years out when I decided on Tymlos. I am sensitive to meds and Tymlos felt safe with its adjustable dose. As you may know, I could not handle the full dose and went down to 1/4 dose and ramped up. I had excellent gains on Tymlos.

My doctors have not followed Tymlos with Evenity for any other patient but I convinced him. I did 4 months, two of them 1/2 dose. This week I am doing a 20% dose of Reclast (due to kidney disease and afib). We have to make these meds work for us!