Thanks for following up. Knowing that this is a marathon not a sprint and there will be good days, bad days and extremely bad days, I have seen a small improvement and I'll take the win no matter how temporary and how small. Any day I can get out of bed and start my day and being able to function is a good day. Only one dose so far so probably not feeling full affect but the big side effect for me is the onset of sudden fatigue or non sustainable activity. But I'm retired so I can deal with that. Trying to swim but I pay the price even with swim noodles . A bit worried about my muscle mass. 1st follow up labs are next week and maybe I'll know more.