The other lady has reactive Arthritis. Her mayo name is pb50.

I know the name but I don't have any personal experience with taking Simponi. I have inflammatory arthritis along with PMR. I don't have RA but I do have another type of inflammatory arthritis.

The problem you may encounter when you have a combination of things is what might work for one thing might not work for the other thing.

I was diagnosed with PMR after many years of inflammatory arthritis. Generally, inflammatory arthritis of any kind isn't treated with long term Prednisone like PMR is treated. However, Prednisone relieves the pain caused by both PMR and inflammatory arthritis.

PMR alone supposedly does cause any permanent damage. Inflammatory arthritis does cause permanent joint damage. Simponi is another TNF-inhibitor . There are many TNF-inhibitors that are used to treat RA and other types of inflammatory arthritis. However, TNF-inhibitors haven't been shown to be effective for PMR.

I always tell people they won't know what works unless they try it to see. A TNF-inhibitor might work for you but there is never any guarantee. My only experience with a TNF-inhibitor is with Humira --- it didn't work for me. Humira was easy to stop when it didn't work so no harm was done. That is a big problem with Prednisone because it isn't easy to stop in case of side effects but it effectively relieves pain for many conditions so not just PMR.

What worked for me was Actemra. It is a IL-6 inhibitor that was targeted at PMR. For me, Actemra worked for PMR and has been beneficial for my type of inflammatory arthritis. I have been off Prednisone for 3 years so I'm very pleased with Actemra.