I had tried at least ten different antidepressants before my doctor prescribed Effexor, and I can't begin to tell you what a huge difference it has made in my life. Picture the movie, The Wizard of Oz, when the color goes from black and white to color. I will be on this medication for the rest of my life, but have successfully weaned down from a high dose to a much lower one. Don't be afraid to try this med. It could be as life-changing for you as it has been for me.