I took the 80mg everyday same time for a little over a month. I couldn’t handle the side effects which included fatigue, occasional diarrhea, skin dryness, itchiness, and almost constant mild headache. My oncologist dropped me to one 80mg pill every other day and I feel so much better. The side effects do come back on the day I take the pill but overall I’m much better. I’m stage 1b cancer with no Mets and an upper lobectomy a 3.5 months ago. So the Tagrisso is purely to help stop any cancer returning. I hope the lower frequency works 🙏🙏🙏….Stay strong !!