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My husband who had Parkinson's was sundowning. Once i found him at 9am face down in the dirt, hypothermic. He had to go to the emergency room.
On my own, I started giving him 10 mg of melatonin at 4 pm and another dose at 9pm. He never sun downed again, except for one time when my son forgot to give him his first dose until 6pm.
I took care of him until he passed on. I spaced out during that awful time by coloring in adult coloring books with gel pens. He could be raging around me and while coloring ,it just slipped over my head. It is a sort of Zen.
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I wonder if it might help to back off on the Seroquel dosage and try the melatonin for her.
So do you color while he carries on and basically ignore the behavior unless of course he would hurt himself or you? When my husband flips to bizarre he often is close by me and starts the accusations re where have you been, what man where you with, on and on and I haven't moved from my chair. I usually try to ignore but have answered back when the accusations are particularly hurtful and my patience is shot. That of course only makes it worse.
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I understand completely. Singing and playing classic country and Gospel music tends to do that for me. Working on my old repertoire, adding some new ones, getting lost in the music. "Music is nourishment for the soul."
And a great distraction to boot.