"At present I'm taking methotrexate, prednisone, duloxatine and lyrica. With minimal relief."

I remember taking all those medications but not all of them at the same time. I probably relied on prednisone too much because I took very high doses of prednisone for a very long time.

I can only imagine what PMR on top of RA is like.

I had PMR on top of reactive arthritis (ReA) so I imagine the combination of PMR and RA is not good.

I don't have any experience with CBD oil and PEA. Now I only do a monthly infusion of a biologic called Actemra (tocilizumab). I don't seem to need prednisone anymore or any other pain medications except maybe Tylenol (acetaminophen) once in a while.

Have you ever tried a biologic to treat RA? There are many biologics suitable for RA.

There aren't too many biologics for PMR but that is beginning to change. There is one biologic called Kevzara (sarilumab) that is FDA approved for both RA and PMR.