← Return to Have had 2 Reclast infusions and may need a tooth extraction.

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@gently

Janetws, osteonecrosis of the jaw is one of the adverse effects of bisphosphonates like Reclast. The incidence is very low, but you shouldn't have the tooth removed while on Reclast. Maybe switch to Forteo in August.

"Bisphosphonates inhibit bone resorption by causing osteoclast cell apoptosis, impairing the osteoclast’s resorptive capacity, and preventing osteoclast formation.[5] They have a high affinity for bone minerals and accumulate mainly in the sites of osteoclast activity.[5] Without resorption and new bone formation, old bone survives beyond its lifespan, and its capillary network is not maintained, leading to avascular necrosis of the jaw. "
https://www.imrpress.com/journal/FBE/3/1/10.2741/E251

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Replies to "Janetws, osteonecrosis of the jaw is one of the adverse effects of bisphosphonates like Reclast. The..."

Thank you for replying to my post!!! I will not have the tooth removed now and will make an appointment with my endocrinologist at Mayo in Rochester. I have a ‘dexa’ scan scheduled for August 8.