Thank you for responding. I have been on Avastin for little over a year now, along with Keytruda, and Cytoxan. Once I started on this "cocktail", my CA-125 was in normal range until October last year, when the melanomas popped up, and it is continuing to rise. I get PET scans after three chemo cycles, and they check the CA-125 every cycle. I try not to worry too much about the rising CA-125, although it has gone up considerably, but try to focus on the PET scans being good - no activity or new implants. I had the debulking done in May 2022. Things looked good for a few cycles, but by August 2022, the CA-125 started going up so my oncologist started me on my second "cocktail" of chemo drugs. That worked for a while, but in March 2023, on my birthday of all things, CT scan was done and it showed small growth in size of a few remaining implants that were still there. That is when I was switched to my current regime of Avastin, Keytruda, and Cytoxan, which has worked well for me. I have been blessed not to have suffered any serious issues with chemo drugs, other than when I was on Doxil, which made my hands like they were sunburned, and the skin peeled and I was unable to bend fingers much. Other than fatigue, I feel okay most of the time. Sometimes it's hard for me to even realize I have this horrible disease going on inside of me. I try to remain positive, as there is so much negative stuff out there on length of life after diagnosis (which is why I try not to read much of it), but I remain positive, as I have a friend, who has a friend that was diagnosed with Stage IV OC, and she is still going at roughly 14 years post her diagnosis, so I do not give up hope. I admit, when diagnosed, I thought my life was over and I was devastated. I had worked with a woman who was diagnosed with OC back in 1998 and she died in 1999. I did not realize how far they had come with treatments. My first visit with the oncologist after diagnosis made me feel so much better, when I was told it is treatable. I give credit to God for giving the doctors the knowledge to know the best treatment for me, and prayers of family and friends. I know it is in His hands so I try not to dwell on it. But, I still seek an answer for rising CA-125...