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Hormone Replacement starting at 75yrs old

Women's Health | Last Active: May 3 1:00am | Replies (194)

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@loribmt

Hi @rswartz. Your doctor may be hesitant to have you start HRT because nicotine can interfere with this medication.

According to an article in PubMed, from the National Institute of Health, “It has been proven that, depending on the type, duration and intensity of nicotine consumption, smoking can reduce or completely cancel the efficacy of orally administered estrogens. Not only does smoking diminish the otherwise well-established beneficial effects of estrogen on hot flashes and urogenital symptoms and its positive effects on lipid metabolism, i.e. by reducing cholesterol, but smoking also specifically reduces estrogen's ability to prevent osteoporosis.”
Here is the complete report:
https://pubmed.ncbi.nlm.nih.gov/15638743/
It sounds as though your doctor may have concerns that the medication won’t be able to work as well as intended for you. Are you having menopause symptoms?

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Replies to "Hi @rswartz. Your doctor may be hesitant to have you start HRT because nicotine can interfere..."

I noticed that the study seems to refer only to orally administered estrogen. What about transdermal or pellet estradiol?