h8bigbiz. We're so different and treatment is as well. I took Xifaxan for ??IBS (my diagnosis) and it worked great. A year of so later my symptoms ramped up so I was prescribed Xifaxan again but it did not work as it did before. Later on I had another colonoscopy and my GI doc did multiple biopsies throughout my colon which revealed microscopic colitis. I was ordered Budesonide for 3 months. Results was amazing. All was great and then a year later the diarrhea plagued me again--5-6 trips to the bathroom every day. I just finished the 3 months last week. The good results came within a couple of days and continues now. If I had to go through the treatment every year or two, it is well worth it. Good luck.