I stared using CBD oil for Restless Legs Syndrome (RLS). It has been amazing. Within 48 hours I was able to reduce my medication for RLS (pramprexole – dopamine based) by 1/3. I would like to keep going with it, but am on hold for right now, because I am concerned about the effect of CBD on blood coagulation. (I had a minor ischemic stroke about 10 years ago and have been on Plavix since.) The “obese rat” study keeps coming in my my searches for research-based information on this topic, but other than that, I haven’t found much. Anyway, my hopeful goal to to use CBD to assist in withdrawing (extremely gradually) from the pramprexole. I have to tell my doctor all this, and am afraid to.