Hi. I had my first infusion on Friday for anal cancer. It went well and was done through a port. I’ll only need one more in a month (as far as we know) as I take two chemo pills in the AM and two PM, plus radiation M-F. On the second day after infusion, extreme fatigue, chills, no appetite, constipation, slight nausea, and then the diarrhea hit this morning. Argh! While that’s unpleasant, I hate nausea more. I now have an anti nausea med from the doctor and it’s helping a lot. I feel better. Still quite weak. Just thought I’d share so you know you’re not alone in this. Best wishes!