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@elke1211 First of all, welcome to Mayo Clinic Connect. It really sounds like you have been trying so many different remedies. Is there any one or group that seems to have worked better than others? How long have you been living with major depressive disorder [MDD]? Sometimes it seems a combination works the best, rather than one thing in particular. Finding the "just right for me" combination can take a lot of patience, trial-and-error, and awareness. This may all be what you've heard before, but it bears repeating.
Starting from the beginning again, my suggestion is a complete physical, to rule out any organic causes or situations. Then move forward with tracking down how to work with your MDD. Diligent note-taking, journaling everyday or so, to get things out of your mind and onto paper, may present a pattern to you to see what triggers are, and give you something to focus on to solve. Does that sound doable?
Ginger
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I have done many of these interventions in tandem. I continue to retry things. I have been struggling 30 years. I’ll continue to try and journal. Just had a physical again last month and a thyroid ultrasound. So far groups have not been helpful since my teen years. I had hope then. I thought life could be better. I work in psychology, so I feel like I should be able to figure out new interventions. I just continue to try.