Thanks for this discussion, it has helped me seek out and begin to use Trimix for my ED problems. I am 63 and have not have prostate cancer but have had ED for years. Sildenafil has worked but slowly it became hit and miss, even with going to the 100 mg dose. Trimix is wonderful, it's been a while since I was firm enough for penetration. And yes, my wife is happy too. However, I've found that it takes an aggressive amount of stimulation to ejaculate. I'm just starting out and should be happy with the results but wondered if anyone has experienced this and if there are any remedies.