I was originally on the big 3, one of which was Rifampin, for 18 months. Then I was off for a little over a year, then unfortunately I had to go back on because MAC came back. Within 5 weeks, the Rifampin caused complete kidney failure, acute tubular necrosis. I was hospitalized for 3 weeks and had to endure dialysis. I am at 55 GFR and 1.12 creatinine but I feel good. I am now on Azith, Ethambutol and Clofazimine and doing well. Hope to be off all meds in another 4 months or so. Apparently reintroduction of Rifampin has a rare side effect of kidney failure. Guess I just got lucky.