← Return to How do you know if your cancer has genetic mutations?

Discussion

How do you know if your cancer has genetic mutations?

Pancreatic Cancer | Last Active: Sep 23 12:41pm | Replies (34)
Comment receiving replies
@gamaryanne

You mention that KRAS is now targeted with specific small drug molecules. Please name what these drug or drug combinations are and if primarily for KRAS g12c? I have not uncovered anything for kras g12d. Thank you!!

Jump to this post

Replies to "You mention that KRAS is now targeted with specific small drug molecules. Please name what these..."
vannkraken | @vannkraken | Jul 16 11:52pm

Not sure if this got answered for you, yet. My wife was recently diagnosed with Stage IV non-operable Pancreatic Cancer and we are awaiting her Tempus tumor analysis results. This is a trial I would look into if you or a loved one have a confirmed KRAS g12d mutation. This is one of the first RAS(ON) inhibitor drugs that is not localized to g12c - the compound is RMC-6236 from Revolution Medicines. The Phase III final protocol is being reviewed by FDA and the company is looking to start enrolling the trial by the end of 2024 - the results in the Phase I/Ib look very promising.

I can't post it because my account is new, but there is a link to the presentation to investors on the proposed Phase III that was just held yesterday, 7/15/24 at the Revolution Medicines website on the "Events & Presentations" tab.

VIEW AND REPLY