← Return to Switching from anastrozole to exemestane: Anyone made this switch?

Discussion

Switching from anastrozole to exemestane: Anyone made this switch?

Breast Cancer | Last Active: Jun 7 9:02am | Replies (27)
Comment receiving replies
@thora902

I am on Exemestane and my oncologist told me to be careful of phytoestrogens. I said doesn't the AI block estrogen? And he said no, Exemestane does not block estrogen, it only keeps your body from making it. Has anybody else been told this? I am concerned because all the healthy foods contain phytoestrogens: beans, legumes, whole grains, broccoli, cabbage, kale, fruits, flax seed, etc. I am also taking chamomile as a sleep aid - and there is a warning on the MSK website saying that people with hormone sensitive cancer should not be given this.....

Jump to this post

Replies to "I am on Exemestane and my oncologist told me to be careful of phytoestrogens. I said..."
reginacrick | @reginacrick | Jun 2 3:22pm

What? Are you serious? I will definitely ask my oncologist about this.. that’s crazy, doesn’t even make sense to me.. thank you !

VIEW AND REPLY
myoga | @myoga | Jun 2 4:42pm

AIs prevent body from making estrogen. Exemestane is steroidal and irreversible, so it tends to have long term effect compared to Anastrozole. I will ask my onco about photoestrogen effect in breast cancer. I found this article about this article about phytoestrogen effect on breast cancer, the conclusion is particularly interesting. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776930/
I also remember reading some where that low breast cancer in Asia is linked to high consumption of soy.
" In conclusion, in this review, none of the selected studies found statistically significant adverse effects of soy consumption on BC recurrence or mortality (specific or all-cause). Almost all studies showed beneficial effects of soy isoflavone intake, in variable ways, on BC recurrence and mortality. These results coincide with other recent works and suggest that soy isoflavone intake is safe for BC survivors.

However, in order to confirm the current results, larger studies are needed. Future research should have larger sample sizes, more accurate assessments of soy isoflavone intake (and total phytoestrogen intake), better control of confounding factors, and longer follow-ups."

VIEW AND REPLY
Rom828 | @jgallagher04921 | Jun 5 5:29am

My oncologist did not tell me this! I was under impression all 3 AIs worked the same way. I'll be asking about this!

VIEW AND REPLY