Connect
← Return to Anyone have experience with liver lesions from pancreatic cancer?
Discussion
Anyone have experience with liver lesions from pancreatic cancer?
Pancreatic Cancer | Last Active: Jun 3 9:41am | Replies (74)Comment receiving replies
It is called something that begins with an O..Onivide I think it is spelled
He has his chemo treatment every other week
He is in the clinic while this chemo is infusing for about an hour
Then he gets something to enhance the chemo called Leukovorin for 30 minutes
Then is is attached to a pump with 5 FU infusing for 46 hours
We go home and come back 2 days later when that has finished infusing and it is disconnected
Then he is free for 12 days
Dana Farber in Boston
Replies to "It is called something that begins with an O..Onivide I think it is spelled He has..."
Connect
The chemo regimen he is receiving is Nalirifox if it contains Onivyde. This drug is micro particles of irinotecan with a liposomal,coating. It gives the drug the ability to be more deeply internalized into the cell and then the high concentration of irinotecan is released. It remains in the body longer for enhanced cytotoxic effects. It was recently approved by the FDA in February 2024.
The title of the abstract is “Comparitive effectiveness of MALIRIFOX vs. FOLFIRINOX in pancreatic cancer. Authors are Xiayu Jiao of Department of Pharmaceutical and Health Economics, USC Schaefer Center, Los Angeles, CA and Afsaneh Barzi from City of Hope Comprehensive Cancer Center, Duarte, CA.
https://ascopubs.org/doi/10.1200/JCO.2024.42.16_suppl.4160
Conclusions of the study:
Compared to Folfirinox, there is slightly higher Quality Adjusted Life Years.
Marginal Progression-Free Survival
While the cost of treatment using Nalirifox is significantly more (56%) than using (m)Folfirinox, some of that is offset when comparing adverse event rate of Neutropenia, Febrile Neutropenia, Anemia, Diarrhea and Thrombocytopenia and its monthly management costs being lower with Nalirifox of 3:1.