Hello @rfsau140, Welcome to Connect. There are a lot of causes for neuropathy. Without testing and seeing a neurologist or specialist, a GP doc can tell you what they think might be the cause but it's just an educated guess. I had the neuropathy symptoms that started in my toes and I went 20+ years before bothering to get a diagnosis. My Mayo neurologist diagnosed me with idiopathic small fiber peripheral neuropathy and sadly I didn't have any better answers for what helps my numbness I was told by my PCPs over the years - nothing helps with the numbness and there is no cure for neuropathy. That's really why I joined Connect in 2016 when I wanted to learn what others with similar symptoms have learned. My neurologist did mention that my neuropathy could possibly be hereditary. I also have family members and cousins with similar neuropathy symptoms. I posted my neuropathy journey in another discussion here - https://connect.mayoclinic.org/comment/310341/.

Best suggestion I have is to learn as much as you can about neuropathy, your symptoms and what treatments may be available that might help. There are a lot of different discussions in the Neuropathy Support Group. It might be helpful to scan through them to see if there are ones that might be helpful. Here's a link to the discussions in the Neuropathy Support Group - https://connect.mayoclinic.org/group/neuropathy/.

Here are a few references you might find helpful for learning more about neuropathy:

Foundation for Peripheral Neuropathy:
-- Living Well with PN: https://www.foundationforpn.org/living-well/
-- Webinars on YouTube: https://www.youtube.com/@foundationforperipheralneu4122/videos

Matthew B. Jensen, Assistant Professor of Neurology, University of Wisconsin has some really easy to understand videos that help learn more about how neuropathy is diagnosed, the symptoms and more on his YouTube Channel here https://www.youtube.com/@MatthewBJensen.

Have you thought about having any genetic testing done or seeking a diagnosis with a neurologist?